The importance of the gut microbiome for our body
The gut and its diverse bacteria influence all bodily processes. They interact with all organs, which is why a balanced gut microbiome is of enormous importance. If toxic or pro-inflammatory bacteria predominate for an extended period, various diseases can be promoted.
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The gut is in direct connection with the immune system and is crucial for infection defense. Good gut bacteria produce short-chain fatty acids such as acetate, butyrate, and propionate, which have anti-inflammatory and antioxidant effects. These fatty acids also interact with immune cells, modulating their activation, differentiation, and survival in various tissues. “Gut Bacteria – Preventive Measure for IBD”
How the Gut and Lungs Communicate
The gut and lungs mainly communicate via the immune system. The digestive tract is constantly exposed to pathogens or allergens that are taken in through the airways. Disturbances in the balance of gut microorganisms can strongly affect the lung's immune responses. Conversely, the lungs send signals back to the gut through programmed cells or pro-inflammatory molecules.
The gut tissue is in bidirectional exchange with the lungs. Short-chain fatty acid-producing bacteria play an important role in this “crosstalk.” A deficiency of these bacteria can promote respiratory diseases. (Photo: Graphic: Stephan Spitzer, E. Wolf, 2021)
Conclusion
A balanced gut microbiota has a positive effect on the immune system. In particular, the production of short-chain fatty acids triggers anti-inflammatory reactions. The gut-lung axis can be supported through regular exercise, a fiber-rich diet, and the administration of probiotics. Imbalances in the gut, e.g., due to smoking, antibiotic use, or infections, are often associated with lung diseases such as asthma or COPD.
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Sources:
- E. Wolf, Pharmazeutische Zeitung, 2021: Respiratory Diseases – How the Gut Protects the Lungs
- T. Fuchs, Georg Thieme Verlag KG, 2018: Gut and Lungs: Interaction via the Microbiota